Impact of Health on Particle Size of Exhaled Respiratory Aerosols: Case‐control Study
Identifieur interne : 000046 ( France/Analysis ); précédent : 000045; suivant : 000047Impact of Health on Particle Size of Exhaled Respiratory Aerosols: Case‐control Study
Auteurs : Guillaume Hersen [France] ; Stéphane Moularat [France] ; Enric Robine [France] ; Evelyne Géhin [France] ; Sandrine Corbet [France] ; Astrid Vabret [France] ; François Freymuth [France]Source :
- CLEAN – Soil, Air, Water [ 1863-0650 ] ; 2008-07.
English descriptors
- Teeft :
- Airborne transmission, Background noise, Bond paper, Centre scientifique, Corona virus, Correction factor, Correction factors, Correlation circle, Data matrix, Diagrammatic representation, Droplet, Elpi, Experimental infection, Fine particles, Health impact, Health status, Healthy individuals, Impactor, Influenza virus, Loose cough, Particle loss, Particle size, Particle sizes, Present study, Pressure impactor, Principal component analysis, Qualitative variables, Respiratory aerosols, Respiratory syncytial virus, Respiratory viruses, Second factor, Size distribution, Size distributions, Specific size distribution, Stain marks, Statistical similarities, Symptom, Symptomatic individuals, Symptomatic ones, Symptomatic volunteers, Symptomatics, Symptomatics factor, Test subjects, Verlag gmbh, Veterinary microbiol, Volunteer, Wide range.
Abstract
Individuals with viral infection could possibly emit an infectious aerosol. The distinction between exhaled breaths of infected and healthy individuals should facilitate an understanding of the airborne transmission of infections. In this context, the present study is aimed at distinguishing healthy individuals from symptomatic ones by the study of their exhaled breath. A setup composed of a modified hood connected to an electrical low pressure impactor, which allows for the study of a wide range of particle sizes (from 7 nm to 10 μm), has been developed in order to collect exhaled breaths. This setup has been used with seventy eight volunteers. The results obtained using Principal Component Analysis (PCA) showed that exhaled breaths of individuals without symptoms have statistical similarities and are different from those of individuals with symptoms. This separation was made by the greater proportional emission by individuals with symptoms of particles collected on stages 3 (D50 = 0.09 μm), 6 (D50 = 0.38 μm), 8 (D50 = 0.95 μm), 10 (D50 = 2.40 μm), and 12 (D50 = 4.02 μm) of the impactor. There was not a specific size distribution obtained for the individuals with symptoms. As a consequence, further research on the exhaled breath should be undertaken with symptomatic volunteers and would require the analysis of this wide range of particle sizes.
Research Article: The distinction between the exhaled breaths of infected and healthy individuals should facilitate an understanding of the airborne transmission of infections. This study is aimed at distinguishing healthy individuals from symptomatic ones by the study of their exhaled breath using a novel setup to collect exhaled breaths for the study of particle sizes. The results were analyzed using Principal Component Analysis (PCA).
Url:
DOI: 10.1002/clen.200700189
Affiliations:
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type="ISSN">1863-0650</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Airborne transmission</term><term>Background noise</term><term>Bond paper</term><term>Centre scientifique</term><term>Corona virus</term><term>Correction factor</term><term>Correction factors</term><term>Correlation circle</term><term>Data matrix</term><term>Diagrammatic representation</term><term>Droplet</term><term>Elpi</term><term>Experimental infection</term><term>Fine particles</term><term>Health impact</term><term>Health status</term><term>Healthy individuals</term><term>Impactor</term><term>Influenza virus</term><term>Loose cough</term><term>Particle loss</term><term>Particle size</term><term>Particle sizes</term><term>Present study</term><term>Pressure impactor</term><term>Principal component analysis</term><term>Qualitative variables</term><term>Respiratory aerosols</term><term>Respiratory syncytial virus</term><term>Respiratory viruses</term><term>Second factor</term><term>Size distribution</term><term>Size distributions</term><term>Specific size distribution</term><term>Stain marks</term><term>Statistical similarities</term><term>Symptom</term><term>Symptomatic individuals</term><term>Symptomatic ones</term><term>Symptomatic volunteers</term><term>Symptomatics</term><term>Symptomatics factor</term><term>Test subjects</term><term>Verlag gmbh</term><term>Veterinary microbiol</term><term>Volunteer</term><term>Wide range</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Individuals with viral infection could possibly emit an infectious aerosol. The distinction between exhaled breaths of infected and healthy individuals should facilitate an understanding of the airborne transmission of infections. In this context, the present study is aimed at distinguishing healthy individuals from symptomatic ones by the study of their exhaled breath. A setup composed of a modified hood connected to an electrical low pressure impactor, which allows for the study of a wide range of particle sizes (from 7 nm to 10 μm), has been developed in order to collect exhaled breaths. This setup has been used with seventy eight volunteers. The results obtained using Principal Component Analysis (PCA) showed that exhaled breaths of individuals without symptoms have statistical similarities and are different from those of individuals with symptoms. This separation was made by the greater proportional emission by individuals with symptoms of particles collected on stages 3 (D50 = 0.09 μm), 6 (D50 = 0.38 μm), 8 (D50 = 0.95 μm), 10 (D50 = 2.40 μm), and 12 (D50 = 4.02 μm) of the impactor. There was not a specific size distribution obtained for the individuals with symptoms. As a consequence, further research on the exhaled breath should be undertaken with symptomatic volunteers and would require the analysis of this wide range of particle sizes.</div><div type="abstract" xml:lang="en">Research Article: The distinction between the exhaled breaths of infected and healthy individuals should facilitate an understanding of the airborne transmission of infections. This study is aimed at distinguishing healthy individuals from symptomatic ones by the study of their exhaled breath using a novel setup to collect exhaled breaths for the study of particle sizes. The results were analyzed using Principal Component Analysis (PCA).</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Hersen, Guillaume" sort="Hersen, Guillaume" uniqKey="Hersen G" first="Guillaume" last="Hersen">Guillaume Hersen</name></noRegion><name sortKey="Corbet, Sandrine" sort="Corbet, Sandrine" uniqKey="Corbet S" first="Sandrine" last="Corbet">Sandrine Corbet</name><name sortKey="Freymuth, Francois" sort="Freymuth, Francois" uniqKey="Freymuth F" first="François" last="Freymuth">François Freymuth</name><name sortKey="Gehin, Evelyne" sort="Gehin, Evelyne" uniqKey="Gehin E" first="Evelyne" last="Géhin">Evelyne Géhin</name><name sortKey="Moularat, Stephane" sort="Moularat, Stephane" uniqKey="Moularat S" first="Stéphane" last="Moularat">Stéphane Moularat</name><name sortKey="Robine, Enric" sort="Robine, Enric" uniqKey="Robine E" first="Enric" last="Robine">Enric Robine</name><name sortKey="Vabret, Astrid" sort="Vabret, Astrid" uniqKey="Vabret A" first="Astrid" last="Vabret">Astrid Vabret</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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